Delayed effects of subarachnoid haemorrhage on cerebral metabolism and the cerebrovascular response to hypercapnia in the primate.
نویسندگان
چکیده
A technique is described for the production of subarachnoid haemorrhage in baboons and their subsequent recovery for chronic study of cerebrovascular reactivity. The baboons make complete neurological recoveries but the response of their cerebral circulation to hypercapnia is impaired one week later. Baseline values of cerebral blood flow and of cerebral oxygen consumption are unaffected at this time. There is no evidence of hypoxic brain damage.
منابع مشابه
Comparative Efficacy of Meloxicam and Placebo in Vasospasm of Patients with Subarachnoid Hemorrhage
Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...
متن کاملComparative Efficacy of Meloxicam and Placebo in Vasospasm of Patients with Subarachnoid Hemorrhage
Cerebral vasospasm considered to be a serious cause of morbidity and mortality following subarachnoid haemorrhage (SAH).Despite several available therapeutic options, current protocols do not prevent major consequences of vasospasm. Inflammation is believed to play an important role in post-haemorrhagic vasospasm. Meloxicam is a non-steroidal anti-inflammatory drug. The aim of this study was to...
متن کاملLate effects of subarachnoid haemorrhage on the response of the primate cerebral circulation to drug-induced changes in arterial blood pressure.
The ability of the cerebral circulation to maintain a constant level of cerebral blood flow with halothane-induced hypotension and angiotensin-induced hypertension was found to be impaired one week after subarachnoid haemorrhage in the baboon. No evidence of hypoxic brain damage was found. The clinical significance of these findings is discussed.
متن کاملRole of Local Nerves and Prostaglandins in Regulation of Basal Blood Flow and Hypercapnic Vasodilatation of Cerebral Blood Vessels in the Rabbit
The mechanisms underlying cerebral vasodilatation during hypercapnia are not fully understood. To examine the role of nerves and prostaglandins in the regulation of basal blood flow and in hypercapnia-induced vasodilatation in the cerebral blood vessels of rabbit.Cerebral blood flow was measured by laser Doppler flow-meter in 18 NZW rabbits anesthetized with sodium pentobarbital. Tetrodetoxin ...
متن کاملخونریزی خودبخودی داخل مغزی: یافته های سی تی اسکن آغازین، تظاهرات بالینی و عوامل خطر محتمل، بیمارستان امام و رازی تبریز، 78-1375
Spontaneous intra-cerebral haemorrhage (SICH) is a relatively common neurological emergency, that is associated with significant morbidity and mortality. The goal of the present study was to estimate the neuro-imaging findings (initial CT scans), clinical presentation and possible risk factors in intra-cerebral haemorrhages.Methods and Materials: The clinical and radiographic findings of 380 pa...
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عنوان ژورنال:
- Journal of neurology, neurosurgery, and psychiatry
دوره 42 10 شماره
صفحات -
تاریخ انتشار 1979